72934-36-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72934-36-2 name is 1-(4-Chlorophenyl)cyclopropanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzoate (0.93 g, 2.45 mmol) in THF (10 mL) was added 1-(4-chlorophenyl)cyclopropanamine (0.5 g, 2.45 mmol) and Hunig’s Base (1.71 mL, 9.8 mmol). The resulting mixture was refluxed at 80 C. for 16 hs. The precipitate was filtrated through a plug washing with THF to give a crude product that was purified by Biotage eluting with 4/1 to 3/2 hexane/ethyl acetate to give 1.2 g of methyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoro ethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzoate as product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Chlorophenyl)cyclopropanamine, and friends who are interested can also refer to it.
Reference:
Patent; Bristol-Myers Squibb Company; Wang, Tao; Scola, Paul Michael; Zhang, Zhongxing; Yin, Zhiwei; Zhao, Qian; US2013/203758; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics