A common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 870-24-6.
Preparation of 2-aminoethylazide 2-chloroethylamine hydrochlorate (Sigma Aldrich) is solubilized in water (133 g/L) at 80 C. Then sodium azide (3 eq., Sigma Aldrich) is added and the mixture is kept under reflux and magnetic stirring for the night. The mixture is cooled to room temperature then to 0 C. using an ice bath. Potassium hydroxide (same amount as 2-chloroethylamine hydrochlorate, Prolabo) is added and after total dissolution, the product is extracted using diethyl ether. Organic phase is dried over magnesium sulfate (Acros Organics), filtered and finally evaporated to obtain 2-aminoethylazide (20 mol.% yield).
The synthetic route of 2-Chloroethanamine hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITE DE BORDEAUX; Centre national de la recherche scientifique; INSTITUT DES CORPS GRAS ETUDES ET RECHERCHES TECHNIQUES-ITERG; INSTITUT POLYTECHNIQUE DE BORDEAUX; Institut Technologique FCBA; CRAMAIL, Henri; GRELIER, Jean-Pierre Albert Stephane; PICHAVANT, Frederique; DA SILVA PEREZ, Denilson; ALFOS, Carine; CHEMIN, Suzanne Maud; (16 pag.)US2018/2453; (2018); A1;,
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