Some common heterocyclic compound, 54788-38-4, name is 2-Chloro-4-methoxy-1-methylbenzene, molecular formula is C8H9ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 54788-38-4
Intermediate 49a: 1-Bromomethyl-2-chloro-4-methoxy-benzene BR A suspension of 3-chloro-4-methylanisole (2.23 g, 14. 24 mmol), N-bromosuccinimide (2.53 g, 14.24 MMOL), and 70% benzoyl peroxide (493 mg, 1.424 MMOL) in 40 mL CCI4 was heated to reflux at 80C for two hours. The mixture was cooled to room temperature, filtered, and the filtrate was concentrated under rotary evaporator. The residue was purified by flash column chromatography eluting with 5% EtOAc in Hexane to provide 2.25 g of intermediate 49a as a white SOLID. 1H NMR (300 MHz, CDCl3) 8 7.33 (d, 1H, J = 8.48 HZ), 6.93 (d, 1H, J = 2.63 Hz), 6.81-6. 75 (m, 1 H), 4.58 (m, 2H), 3.79 (m, 3H).
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-4-methoxy-1-methylbenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER INC.; WO2005/21554; (2005); A1;,
Chloride – Wikipedia,
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