Adding some certain compound to certain chemical reactions, such as: 622-24-2, name is (2-Chloroethyl)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-24-2. 622-24-2
1-Chloro-2-phenylethane (57.0 mg, 0.41 mmol) and K2CO3 (298 mg, 2.16 mmol) were added to a solution of the secondary amine 3b (58.6 mg, 0.27 mmol) in acetonitrile (10 mL). The mixture was filled into a 10 mL-microwave pressure vial and irradiated with microwaves (program: standard; max. power 180 W; max. pressure 5 bar; temperature 140 C; time program: 5 min ramp time; 25 min hold time; 5 min cool off time). The mixture was filtered through Celite, washed with CH2Cl2, concentrated in vacuo and the residue was purified by fc (1 cm, petroleum ether/ethyl acetate 7:3, 5 mL, Rf = 0.22). Pale yellow oil, yield 40 mg (45%). C21H25NO2 (323.4). Anal. calcd. C 77.99 H 7.79 N 4.33 found C 77.73 H 7.85 N 4.24. MS (EI): m/z = 292 [M+ – OCH3], 232 [M+ – CH2Ph]. IR: (cm-1) = 2939 (nu C-H), 1076 (nu C-O), 752/698 (delta C-H monosubst. benzene). 1H NMR (CDCl3): delta (ppm) = 2.11-2.20 (m, 0.5H, CH2CH2N (cis or trans)), 2.29-2.46 (m, 1.5H, CH2CH2N (cis, trans)), 2.77-3.06 (m, 9H, N(CH2)2Ph (4H), CH2CH2NCH2 (4H), ArCH2CHOCH3 (1.5H; cis, trans)), 3.19-3.24 (m, 0.5H, ArCH2CHOCH3), 3.53/3.54 (2s, together 3H, OCH3 (cis, trans)), 4.80-4.85 (m, 1H, ArCH2CHOCH3), 7.03-7.08 (m, 1H, arom. H), 7.15-7.39 (m, 8H, arom. H). Ratio of diastereomers 52:48.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of (2-Chloroethyl)benzene.
Reference:
Article; Jasper, Annemarie; Schepmann, Dirk; Lehmkuhl, Kirstin; Vela, Jose Miguel; Buschmann, Helmut; Holenz, Joerg; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 327 – 336;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics