627-42-9, A common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, molecular formula is C3H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
p-Acetylphenol (20.0 g, 147 mmol) was dissolved in DMF (200 mL). While cooling on ice, sodium hydride (6.46 g, 0.16 mol, 60% in oil) and then chloromethyl methylether (16.7 mL, 220 mmol) were added to the solution, and the mixture was stirred for 2 hours at the same temperature. The reaction solution was added with ice and saturated aqueous sodium hydrogencarbonate, and extracted with ethyl acetate. After the organic layer was washed with saturated brine, the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was,purified by silica gel column chromatography (n-hexane/ethyl acetate = 9/1), and 4-(methoxymethoxy)acetophenone (23.7 g, 89% yield) was obtained. FAB -MS m/z: [M+H]+ 181.1H-NMR (CDCl3) delta (ppm): 2.56 (s, 3H), 3.48 (s, 3H), 5.23 (s, 2H), 7.07 (d, J = 9.1 Hz, 2H), 7.93 (d, J = 9.1 Hz, 2H).
The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd; EP1431280; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics