Some common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, molecular formula is C4H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1871-57-4
Step 2: ((2-(chloromethyl)allyloxy)methyl)benzeneTo an over-dried flask was added DME (240 mL), sodium hydride (4.12 g, 120 mmol), and then benzyl alcohol (12.4 mL, 120 mmol) was added dropwise. After the addition was complete the mixture was heated to reflux for 1 hour. The mixture was cooled to 0 C in an ice-water bath and 3-chloro-2-(chloromethyl)prop-1-ene (12.7 mL, 120 mmol) was added in one portion. The mixture was heated to reflux for 19 hours, cooled to room temperature, and poured into saturated sodium hydrogen carbonate solution (250 mL). The aqueous layer was extracted with diethyl ether (4×200 mL). The combined organic layers were dried with anhydrous sodium sulphate, filtered, and concentrated in vacuo to give a residue which was fractionated to give ((2-(chloromethyl)allyloxy)methyl)benzene (10.7 g, 45.5%) as a colorless oil. LCMS (m/z, ES+) = 219 (M+1 )
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1871-57-4, its application will become more common.
Reference:
Patent; GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David; WO2012/67663; (2012); A1;,
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