Adding some certain compound to certain chemical reactions, such as: 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104-11-0. 104-11-0
1-Benzyl-3-(4-chloro-phenyl)-3-methyl-1-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-1H-imidazol-4-ylmethyl]-piperidin-4-yl}-urea A solution of p-chloro-N-methylbenzylamine (282 mg) in dichloromethane (10 ml) was treated with pyridine (0.96 ml) followed by a solution of 20% phosgene in toluene (3.1 ml) and stirred at ambient temperature for 16 h. The mixture was quenched by the addition of saturated sodium hydrogen carbonate (10 ml), and the organic layer was en separated, dried (anhydrous magnesium sulphate), filtered and evaporated under reduced pressure. The residue was dissolved in dichloromethane (10 ml) and a solution of N-benzyl-1-[[2-[4-(trifluoromethyl)phenyl]-5-methyl-1H-imidazol-4-yl]methyl]-4-piperidinamine (657 mg) in dichloromethane (10 ml) was added followed by more pyridine (0.96 ml) and the mixture stirred for a further 16 h. The mixture was diluted with dichloromethane (40 ml) followed by brine (2*20 ml). The organic layer was separated, dried (anhydrous magnesium sulphate), filtered and evaporated under reduced pressure. The residue was purified by flash chromotography eluding with 10% methanol in dichloromethane to give the title compound (512 mg, 56%). Mass spectrum 597 [M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-(4-Chlorophenyl)-N-methylmethanamine.
Reference:
Patent; Edlin, Christopher David; Redshaw, Sally; Smith, Ian Edward David; Walter, Daryl Simon; US2003/69276; (2003); A1;,
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