13726-14-2, A common compound: 13726-14-2, name is 4-Chloro-3-methoxyaniline, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Step 3. 2-Chloro-N-(4-chloro-3-methoxyphenyl)-acetamideChloroacetyl chloride (10 mmol) is added dropwise to a mixture of 4-chloro-3-methoxyaniline (1.57 g, 10 mmol), ethyl ether (30 mL) and NaHCO3 (saturated solution, 30 mL) at room temperature and under vigorous stirring. After 1 h at room temperature the layers are separated, the organic layer is washed with NaHCO3 (saturated solution, 2×30 mL), brine (2 x 30 mL), aqueous HC1 (1M, 30 mL), and brine (2 x 30 mL), and dried (MgSO4). The solvent is removed under reduced pressure to produce the title compound as an off-white solid. H-l NMR: 3.91 (s, 3H); 4.18 (s, 2H); 6.90 (dd, 1H); 7.30 (d, 1H); 7.46 (d, 1H); 8.22 (broad, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-methoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEUROGEN CORPORATION; WO2006/15279; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics