In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6775-78-6 as follows. 6775-78-6
b) 3-Bromo-6-chloroimidazo[1,2-b]pyridazine Bromine (3.8 mL, 74.19 mmol) was added dropwise to a solution of 6-chloroimidazo [1,2-b]pyridazine (preparation 1 a, 4.8 g, 31.06 mmol) in glacial acetic acid (80 mL) and the resulting mixture was stirred at room temperature for 20 minutes. The precipitate formed was collected by filtration, washed with diethyl ether several times and dried in vacuo. The solid obtained was partitioned between ethyl acetate and a saturated aqueous solution of potassium carbonate. The organic layer was separated and washed with a saturated aqueous solution of potassium carbonate (x3), dried over magnesium sulphate and the solvent removed under reduced pressure. The crude was then treated with pentane, filtered and the solid obtained was dried in vacuo to yield the title compound (6.6 g, 92%) as a pale yellow solid. LRMS (m/z): 232 (M+1)+. 1H-NMR delta (300 MHz, CDCl3):7.13 (d, 1H), 7.80 (s, 1H), 7.92 (d, 1H).
According to the analysis of related databases, 6775-78-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Almirall, S.A.; EP2463289; (2012); A1;,
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