13726-14-2, A common heterocyclic compound, 13726-14-2, name is 4-Chloro-3-methoxyaniline, molecular formula is C7H8ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2(1-Benzyl-piperidin-4-yl)-(4-chloro-3-methoxy-phenyl)-amine/V-Benzylpiperidone (7.9 ml_, 43,8 mmol), 4-chloro-3-methoxy-phenylamine (6.9 g, 43.8 mmol) and sodium sulphate (31.1 g, 218 mmol) were suspended in dichloromethane (250 ml_). Sodium triacetoxyborohydride (11.4 g, 52.5 mmol) was added and the reaction mixture was stirred at room temperature overnight.Aqueous sodium hydrogencarbonate was added followed by stirring for 30 min.The mixture was extracted with dichloromethane and the combined organic phases were washed with brine, dried over sodium sulphate, filtrated and
The synthetic route of 13726-14-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NEUROSEARCH A/S; WO2009/77585; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics