1871-57-4, A common compound: 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
[0102] A tubular reactor was configured 300 with a static mixer 305, a T-mixer 310 and an elevated temperature stage 322 as illustrated schematically in FIG. 8. An organic stream 328 containing 3-chloro-2-(chloromethyl)prop-1-ene (1 equiv.), CHBr3 (5 equiv.), 18-crown-6 (5 mol %), pinacol (8.5 mol %), and methylene chloride (4 vol.) was mixed with an aqueous33% NaOH stream 329 at about 70C using mixers 305, 310 in the tubular reactor 300 to form1,1 -dibromo-2,2-bis(chloromethyl)cyclopropane 330. Flow rates were controlled by using the back pressure regulator 370 and by using the syringe pumps 335, 340 to deliver the organic and aqueous streams. The mixers 335, 340 were located in the elevated temperature stage 322 as illustrated in FIG. 8 and included a T-junction (T-mixer) 310 and a 29 element in-line static mixer 305 having a diameter about the same as that of the reactor tubing. The static mixer 305 includes counterhelices to achieve mixing of the biphasic stream in laminar flow. The residence time in the elevated temperatures stage 322 was about one hour. The yield of 1,1 – dibromo-2,2-bis(chloromethyl)cyclopropane 330 was – 9%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2-chloromethyl-1-propene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ZENO ROYALTIES & MILESTONES, LLC; PINCHMAN, Joseph, Robert; BUNKER, Kevin, Duane; BIO, Matthew, M.; BREEN, Christopher; CLAUSEN, Andrew, M.; FANG, Yuanqing; LI, Hui; SHEERAN, Jillian, W.; (61 pag.)WO2019/51038; (2019); A1;,
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