118-69-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118-69-4 as follows.
step one:2,6-dichlorotoluene (100 g, 0.62 mol) was added to 1000 ml of dichloromethane at room temperature, and aluminum trichloride (165.6 g, 0.68 mol) was added thereto, and the temperature was controlled below 30 C.Acetyl chloride (97.5 g, 1.24 mol) was added dropwise to the reaction system at a rate of 20 drops per minute.After the completion of the dropwise addition, the temperature was raised to 40 C and refluxed for 12 hours.After the completion of the reaction, the reaction system was cooled to room temperature, and the reaction mixture was poured into 1000 ml of ice water, extracted with dichloromethane (500 ml ¡Á 3), and the organic phase was combined, washed with saturated brine (600 ml ¡Á 2), anhydrous sulfuric acid Magnesium is filtered after drying,The filtrate was concentrated under reduced pressure to give a red brown oil.106 g, crude yield was 84.2%.
According to the analysis of related databases, 118-69-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SHANDONG BESTCOMM PHARMACEUTICAL CO LTD; Shandong Bainuo Pharmaceutical Co., Ltd.; YU YANG; Yu Yang; CHEN JINGJIN; Chen Jingjin; ZHOU HUAYIN; Zhou Huayin; WANG LINYONG; Wang Linyong; ZHANG ZHIQIANG; Zhang Zhiqiang; SUN YUANJUN; Sun Yuanjun; QIU XIN; Qiu Xin; WANG YULIANG; Wang Yuliang; (16 pag.)CN108299480; (2018); A;,
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