433-94-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 433-94-3, name is 2-Chloro-6-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A) 15 g of hydrochloric acid (0.15 mol) are added to the reaction apparatus,After cooling, 9.2 g (0.047 mol) of 2-chloro-6-trifluoromethylaniline was dropwise added to the system,Dropping added insulation reaction 60min,Then sodium nitrite solution 13.5g (0.09mol) was added dropwise to the system,Process temperature 3 ,Dropping added insulation reaction 2h; B) 32 g (0.32 mol) of hydrochloric acid was added to the above system,1.6 g (0.01 mol) of copper sulfate,Stirring until dissolved,Then 33.84 g (0.141 mol) of sodium bisulfite solution was added dropwise,After the addition was complete, the temperature was raised to 60 C. and incubated for 1.5 hours.The reaction is completed and extracted with methylene chloride, separated, the organic phase is dried, filtered, and the solvent is removed to give 2-chloro-6-trifluoromethylbenzenesulfonyl chloride;
The synthetic route of 433-94-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yellow River Delta Jingbo Chemical Institute Co., Ltd.; Yu Long; Yao Gang; Chang Jinlei; Chen Zhimin; Liu Kefeng; Fan Qiyan; (6 pag.)CN106478464; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics