Adding some certain compound to certain chemical reactions, such as: 96558-78-0, name is 3-Bromo-5-chlorophenylamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 96558-78-0. 96558-78-0
To a solution of 3 -bromo-5-chloro- aniline (500 mg, 2.42 mmol) in l,4-dioxane (10 ml) and H20 (1 ml) was added 4, 4,5,5- tetramethyl-2-(2-methylprop- l-enyl)- 1 ,3,2-dioxaborolane (529 mg, 2.90 mmol), Pd(dppf)Cl2 (177 mg, 0.24 mmol) and Cs2C03 (2.37 g, 7.26 mmol). The RM was heated to 120 C for 12 h under N2. The solution was concentrated in vacuo. The residue was purified by FCC (25 % EtOAc in petroleum ether) to give the title compound as a green oil (Y = 41 %). ‘H NMR (400 MHz, DMSO-rf6) d ppm 6.42 (t, J= 2 Hz, 1H), 6.37 (s, 1H), 6.34 (s, 1H), 6.08 (s, 1H), 5.35 (s, 2H), 1.83 (s, 3H), 1.80 (s, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Bromo-5-chlorophenylamine.
Reference:
Patent; NODTHERA LIMITED; HARRISON, David; WATT, Alan Paul; BOCK, Mark G.; (334 pag.)WO2019/121691; (2019); A1;,
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