60633-25-2, Name is 2-Bromo-4-chloro-1-methoxybenzene, 60633-25-2, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
5-Chloro-2-methoxyphenylboronic acid (structure 37 of Scheme XI, where R1 =H, R2 =Cl) This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 2-bromo-4-chloroanisole (2.00 g, 9.0 mmol, 1.0 equivuiv), n-BuLi (2.5M in hexanes; 3.62 mL, 9.0 mmol, 1.0 equivuiv), and trimethylborate (3.0 mL, 26 mmol, 2.9 equivuiv) to afford 1.30 g (77%) of crude 5-chloro-2-methoxyphenylboronic acid as a white semi-solid. This compound was used in the next reaction with no further purification. Methyl (5′-chloro-2′-methoxy-4-nitro-2-biphenyl)carboxylate (structure 39 of Scheme XI, where R1 =H, R2 =Cl)
Statistics shows that 2-Bromo-4-chloro-1-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 60633-25-2.
Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5688810; (1997); A;; ; Patent; Ligand Pharmaceuticals Incorporated; US5693646; (1997); A;,
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