2533-69-9, Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9.
[00748] To a solution of 4-chloro-5-(4-chlorobenzyloxy)benzene-1,2-diamine (282 mg, 1 mmol) in DCM (4 mL) and ethyl ether (1.6 mL) at 0C was added methyl 2,2,2-trichloroacetimidate (260 mg, 1.5 mmol) and TFA (1.6 mL). The resulting reaction mixture was stirred at 15C for 20 h. The reaction was quenched by adding ice, and white solid was formed, and then filtered. The solid was washed with excess DCM. The filtrate was concentrated in vacuo at 20C to give the residue (200 mg) as a tan gum,. The residue was used directly in the next step. ESI-MS (EI+, m/z):
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Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics