Adding some certain compound to certain chemical reactions, such as: 2453-46-5, name is Chlorocycloheptane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2453-46-5. 2453-46-5
A 1.64 M THF solution of phenylmagnesium chloride (1.10 mL, 2.40 mmol) was added at 0 C. to 0.6 mL of a THF solution of aluminum chloride AlCl3 (80.0 mg, 0.60 mmol). The reaction mixture was stirred at room temperature for 1 hour. To the resulting solution was added 1,2-bis(bis(3,5-di-tert-butylphenyl)phosphino)benzene ([3,5-(t-Bu)2]-DPPBz) (13.4 mg, 0.015 mmol) and a 0.1 M THF solution of iron chloride FeCl3 (0.15 mL, 0.015 mmol) at 0 C., followed by chlorocycloheptane (66.3 mg, 0.5 mmol). The coupling reaction was performed at 80 C. for 24 hours. After cooling to room temperature, a portion of the reaction mixture was taken out, and the yield of the product was measured by gas chromatography (GC), using undecane as an internal standard. The yield was 94%. The results are shown in the Entry 5 column of Table 8.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Chlorocycloheptane.
Reference:
Patent; Kyoto University; US2011/152523; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics