104-11-0, The chemical industry reduces the impact on the environment during synthesis 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life.
A solution of amine (70 mg, 0.45 mmol) and IBX (252 mg, 0.90 mmol) in 10 mL of CHCl3 was heated at reflux with vigorous stirring for 4 h. The resulting suspension was filtered and the filtrate was washed in sequence with 10% NaOH (5 mL x 3), 1 M HCl (5 mL x 3), and water. The organic layer was dried with MgSO4 and removed in vacuo to afford the desired product (60 mg, 94% yield). 1H NMR (400 MHz, 25 C, CDCl3): delta = 9.98 (s, 1H), 7.82 (d, 2H, J = 8.0 Hz), 7.51 (d, 2H, J = 8.0 Hz) ppm. 13C NMR (100 MHz, 25 C, CDCl3): delta = 186.22, 136.29, 130.01, 126.24, 124.79 ppm. ESI-MS: M + H+, found 141.7 (calc. 141.57).
The chemical industry reduces the impact on the environment during synthesis 1-(4-Chlorophenyl)-N-methylmethanamine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Chen, Li-Xia; Huang, Yin-Hui; Cong, Hang; Tao, Zhu; Chemical Papers; vol. 72; 3; (2018); p. 661 – 667;,
Chloride – Wikipedia,
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