The chemical industry reduces the impact on the environment during synthesis 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, I believe this compound will play a more active role in future production and life. 56961-77-4
Example 1 1- (2, 3-DICHLOROPHENYL)- [1, 4] diazepine (starting material) 2.25 g (10 MMOL) 1-bromo-2, 3-dichloro-benzene was dissolved in dry toluene (50 ml), 2.3 (11 MMOL) of [1, 4] diazepine-1-carboxylic acid tert-butylester was added followed by 0.2 g BINAP (2,2-bis (diphenylphosphino)-1, 1′-binaphtyl), 85 mg tris (DIBENZYLIDENEACETONE) dipalladium (0) and 1.2 g (12MMOL) SODIUM-TERT-BUTOXYDE. The reaction mixture was refluxed for eight hours and filtered. The organic layer was washed with water, dried and evaporated in vacuo. The residue was purified by chromatography and deprotected at 10 C using 20 ML ETHYLACETATE saturated with gaseous hydrochloric acid, the precipitate was filtered giving 2.1 g (yield : 75 %) hydrochloride salt of the title compound, melting at 182-3 C.
The chemical industry reduces the impact on the environment during synthesis 56961-77-4. I believe this compound will play a more active role in future production and life.
Reference:
Patent; RICHTER GEDEON VEGYESZETI GYAR RT.; WO2005/12266; (2005); A1;,
Chloride – Wikipedia,
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