In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 13078-79-0
Step iii) 3-(3-Chlorophenethylamino)-N-cyclohexyl-N-(2-(2-(8-hydroxy-2-oxo-l ,2- dihydroqumolin-5-yl)etliylamino)ethyl)rhoropanamide bis(trifluoroacetate)Benzyl 2-(N-cyclohexylacrylamido)ethyl(2-(8-hydroxy-2-oxo- 1 ,2-dihydroquinolin-5- yl)ethyl)carbamate (70 mg) [Step ii] and 2-(3-chlorophenyl)ethylamine (63 mg) were combined in ethanol (5.8 niL) and the resulting solution stirred at 50 0C for 18 h. The mixture was then concentrated in vacuo prior to addition of acetic acid (2 mL) followed by 33% HBr in acetic acid (3 mL). The resulting solution was stirred for 3 h then concentrated in vacuo and the residue partially purified by flash chromatography on silica (eluting with 10% methanol in dichloromethane). Product containaing fractions were combined and concentrated in vacuo. The residue was further purified by reverse phase preparative HPLC (eluting with 5-40% acetonitrile in 0.1% aqueous trifluoroacetic acid). Product containing fractions were combined and concentrated in vacuo to afford the title compound as a solid (5 mg) MS (APCI+) 539 [M+H]+1H NMR (399.825 MHz, CD3OD) delta 8.16 (d, J = 9.7 Hz5 IH)5 7.41 – 7.35 (m, 2H), 7.30 – 7.22 (m, 2H), 6.98 (dd, J = 22.2, 8.1 Hz52H), 6.66 (d, J= 10.0 Hz5 IH), 3.65 – 3.57 (m, 3H)5 3.38 – 3.27 (m, 4H), 3.23 – 3.14 (m, 8H), 2.91 (t, J = 6.0 Hz, 2H), 1.88 – 1.82 (m, 2H), 1.79 – 1.74 (m, 2H), 1.70 – 1.63 (m, IH), 1.56 – 1.26 (m, 4H), 1.22 – 1.09 (m, IH).
The synthetic route of 13078-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/75025; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics