29671-92-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 29671-92-9 as follows.
Example 312-amino-N-hydroxy-4-oxo-3,4-dihydroquinazoline-7-carboxamide; Compound I-199 Step 1: methyl 2-amino-4-oxo-3,4-dihydroquinazoline-7-carboxylate; Intermediate-12Into a round bottom flask was added dimethyl 2-aminoterephthalate (1.0 g, 4.8 mmol) mixed with carbamimidic chloride-HCl (1.10 g, 9.6 mmol) and dimethyl sulfone (4.5 g, 47.8 mmol). The reaction mixture was heated to 150 C. and stirred overnight. The mixture was cooled to rt, water added and the solid was filtered. The solid was then washed with acetic acid to afford methyl 2-amino-4-oxo-3,4-dihydroquinazoline-7-carboxylate (1.0 g, 95%). LC-MS: (FA) ES+220
According to the analysis of related databases, 29671-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2012/94997; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics