In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24279-39-8 as follows. 24279-39-8
Reference Production Example 10 First, 31.4 g (120 mmol) of triphenylphosphine and 4.9 g (48 mmol) of triethylamine were added to 20 ml of carbon tetrachloride, to which 3.8 g (40 mmol) of difluoroacetic acid was added dropwise under ice cooling. After completion of the dropwise addition, the mixture was stirred under ice cooling for 10 minutes. Then, a solution of 9.2 g (40 mmol) of 2,6-dichloro-4-trifluoromethylaniline in 20 ml of carbon tetrachloride was added dropwise to the reaction mixture, which was heated at 80 C. for 6 hours. The reaction mixture was concentrated under reduced pressure, followed by addition of hexane, and undissolved matter was removed by filtration. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 6.0 g of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2-difluoroacetimidoyl chloride. 1H-NMR (300 MHz, CDCl3/TMS): delta (ppm)=7.65 (s,21), 6.38 (t, J=54.1 Hz, 1H)
According to the analysis of related databases, 24279-39-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Matsumoto, Osamu; Uekawa, Toru; US2001/41740; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics