933190-51-3, Adding some certain compound to certain chemical reactions, such as: 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 933190-51-3.
Comparative Example 1 e 8-Bromo-6-chloro-3-iodoimidazo 1 ,2-b]pyridazine A mixture comprising 100 g (430 mmol) 8-bromo-6-chloroimidazo[1 ,2- b]pyridazine which was prepared according to a procedure described in US2007/78136 (WO2007/38314), 145 g N-iodosuccinimide, 5 percent per weight cone, hydrochloric acid and 1 L trichloromethane was heated at reflux for 6 hours. 20 g N-iodosuccinimide were added and heating was continued for additional 3 hours. The precipitate was removed and the filtrate was washed with 1 N sodium hydroxide solution, brine and dried over sodium sulfate. After filtration and removal of solvent diisopropyl ether was added and the residue was stirred at 23 C overnight. The precipitate was filtered off and dried to give 66.6 g (43%) of the title compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 933190-51-3.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; WENGNER, Antje, Margret; SIEMEISTER, Gerhard; WO2014/198776; (2014); A1;,
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