A common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6940-78-9.
At 20 ~ 30 C, under stirring to N,N-dimethylformamide (1000 ml) was added 7-hydroxy-1H-quinolin-2-one (200.0 g) and potassium hydroxide (205.3 g, 1.2 eq), 240 ml of pure water was slowly added to the mixed solution at a controlled temperature of <40 C. The mixture was stirred at room temperature for about 15 minutes and 1-chloro-4-bromobutane (422 g, 2.0 eq) was added in one portion and then stirred at 40 C. for 5-6 h . The mixture was stirred for 1 h at room temperature and filtered. The cake was beaten by stirring in 1000 ml of water for 1 h, filtered, and the filter cake was refined in 10 times of methanol to obtain 240 g of the title compound (3) (yield: 77.0%).
The synthetic route of 1-Bromo-4-chlorobutane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui Runsheng Pharmaceutical Co., Ltd.; Sun Mingzhe; Fang Cunjie; Zhao Dongsheng; Fang Congbin; Sun Yanbiao; Xu Kui; (4 pag.)CN106496206; (2017); A;,
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