In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2729-34-2 as follows. 2729-34-2
General procedure: To a mixture of compound 19 (211 mg, 1.3 mmol, 1.0equiv) inethanol (10 mL) at 60 C, 18a (351 mg, 1.3 mmol, 1.0 equiv) wasadded. The reaction was stirred for 10 min, and then a warm sodiumbicarbonate solution (328 mg in 5mL water) was added over15 min. The reaction was stirred at 60 C for 1 h and then cooled toroom temperature. After extraction with ethyl acetate, the combinedorganic phase was dried over sodium sulfate and concentratedto give 20a as a crude brown solid (515 mg, 80%).
According to the analysis of related databases, 2729-34-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Chen, Shulun; Guo, Wei; Liu, Xiaohua; Sun, Pu; Wang, Yi; Ding, Chunyong; Meng, Linghua; Zhang, Ao; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 38 – 55;,
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