The chemical industry reduces the impact on the environment during synthesis 1127-85-1, name is 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, I believe this compound will play a more active role in future production and life. 1127-85-1
to stire solution of 2,4-dichloro-5,6,7,8-tetrahydroquinazoline (6.46g, 18.8 mmol) in THF(5 mL) was added (rac)-(28,38)-methyl 3-aminobicyclo[2.2.2]octane-2-carboxylate (1.99 g,20 10.8 mmol) and DIPEA (4.2 g, 5.68 mL, 32.5 mmol) and the resulting reaction mixturesolution was stirred at 70 oc for 12 h. After cooling to room temperature, the reactionmixture was poured into water (1 00 mL) and extracted with EtOAc (150 mL twice). Thecombined organic layers were washed with brine, dried over anhydrous Na2804 , filteredand concentrated in vacuo to give a crude product, which was purified by silica gel flash chomatography (0-40% EtOAc-hexane gradient) to afford the title compound ( 1 g, 26.4%yield) as white foam. MS: 350.1 [M+Ht
The chemical industry reduces the impact on the environment during synthesis 1127-85-1. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; TAN, Xuefei; ZBINDEN, Katrin Groebke; KUHN, Bernd; WANG, Lisha; LIU, Yongfu; WU, Jun; SHEN, Hong; SHI, Tianlai; (174 pag.)WO2017/133664; (2017); A1;,
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