72235-56-4, These common heterocyclic compound, 72235-56-4, name is 3-Chloro-4-fluorobenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of 3-[(3-chloro-4-fluorobenzyl)amino]-1-propanesulfonic acid To a solution of 3-chloro-4-fluorobenzy]amine (1.0 g, 7.8 mmol) in Acetone (2 mL) and Toluene (2 mL) was added 1,3-propane sultone solution (1.5 M in THF, 4.0 mL, 6.0 mmol). The solution was stirred at reflux for 4 hours. The reaction mixture was cooled to room temperature. The solid material was collected by filtration and washed with acetone (2*5 mL) and dried in a vacuum oven at 50 C., affording the title compound, 0.041 g (2%). 1H NMR (D2O, 300 MHz) delta ppm 7.44 (dd, 1H, J=2.2 Hz, 6.9 Hz), 7.25 (m, 1H), 7.15 (t, 2H, J=8.6 Hz), 4.07 (s, 2H), 3.07 (t, 2H, J=7.8 Hz), 2.83 (t, 2H, J=7.5 Hz), 1.98 (m, 2H). 13C (D2O, 75 MHz) delta ppm 160.07, 156.77, 132.18, 130.43, 130.22, 127.90, 120.94, 117.58, 117.29, 50.20, 48.17, 46.09, 21.67. 19F (D2O, 282 MHz) delta ppm -115.33. ES-MS 280 (M-1).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 72235-56-4.
Reference:
Patent; Kong, Xianqi; Wu, Xinfu; Bouzide, Abderrahim; Valade, Isabelle; Migneault, David; Bellini, Francesco; US2006/183800; (2006); A1;,
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