202197-26-0, Name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, 202197-26-0, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
3-Chloro-4-((3-fluorobenzyl)oxy)aniline (12.58 g, 50 mmol) was added to 100 ml of benzene and stirred well.0.4 g of acetic acid (as a catalyst) was added, followed by dropwise addition of trimethyl orthoformate (2.65 g, 25 mmol) with an addition funnel at room temperature.After the completion of the dropwise addition, the Dean-Stark apparatus was installed, and the reaction mixture was placed in an oil bath and heated to 80 C for 1 hour.The Dean-Stark device collects ethanol; then the temperature is raised to 110 C for 2 h, after the reaction is finished, it is cooled to room temperature and placed in an ice bath.The solid was filtered, and the filter cake was washed with a little toluene to give (E)-N’-(3-chloro-4-((3-chlorobenzyl)oxy)phenyl)-N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)carboxamidine 11.9 g, yield 89.9%.
Statistics shows that 3-Chloro-4-((3-fluorobenzyl)oxy)aniline is playing an increasingly important role. we look forward to future research findings about 202197-26-0.
Reference:
Patent; Yancheng Normal College; Nanjing University Of Technology Dafeng Ocean Industrial Institute; Sun Yaquan; Zong Chaoyang; Gu Huiwen; (10 pag.)CN108440420; (2018); A;,
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