108-70-3, name is 1,3,5-Trichlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 108-70-3
To a 250 ml single-necked flask was placed 9.5 g (52.4 mmol) of 1,3,5-trichlorobenzene and 100 ml of ultra-dry tetrahydrofuran under argon protection and minus 78 degrees Celsius. Then, 26.3 ml (2 Torr, 52.6 mmol) of lithium diisopropylamide in tetrahydrofuran/n-hexane solution was added dropwise, and the mixture was stirred at minus 78 C for 30 minutes. Then, 10.0 g (47.7 mmol) of Compound A1 was added, and stirring was continued for 2 hours at minus 78 C. The reaction was then slowly warmed to room temperature and quenched by the addition of 200 mL of saturated aqueous ammonium chloride. The combined organic layers were washed with brine (25 mL) After evaporating the solvent, it was purified by column chromatography using methylene chloride: petroleum ether: 1:1 (volume ratio) as eluent to afford 17.5 g of product A2, yield 94%.
Statistics shows that 108-70-3 is playing an increasingly important role. we look forward to future research findings about 1,3,5-Trichlorobenzene.
Reference:
Patent; Jilin University; Li Feng; Ai Xin; Zhang Ming; (25 pag.)CN108191739; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics