41965-95-1, A common compound: 41965-95-1, name is 3-Chloro-4-methoxybenzylamine Hydrochloride, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
A mixture of 4 (0.12 mmol), 3~ehoro-4-methoxyhenzylamine hydrochloride (0.12 mmol), Nal (0.006 mmol), and phenol (0.12 mmol) was heated at 130 “C for 2.5 h. The reaction mixture was diluted with Et20 ( 10 mL) and washed with IN NaOH (3×5 mL). The organic layer was dried over Na2S0 , filtered and evaporated under reduced pressure. The residue was purified by Flash Chromatography (AcOEt: MeOH 8:2) to give the desired compound B (33% of yield). MS ESI (m/z) 394 (M+ j ), H NMR (300 MHz, CDCI3) delta 8.32 (d, 1 H, J= 1.2 Hz), 7.97 (d, 1H, J= 8.7 Hz), 7.71 (dd, 1H, J,= 1 .8, J2= 8.7 Hz), 7.37 (d, 1H, J= 2.1 Hz), 7.18 (dd, 1H, Jx= 2.4, J2= 8.7 Hz), 6.94 (d, 1H, J- 8.4 Hz), 4.57 (d, 2H, J= 6.0 Hz), 4.1 1 (br s, 1H), 3.92 (s, 3H), 3.54 (s, 2H), 3.22 (t, 2H, J= 6.3 Hz), 2.83 (t, 2H, J= 6.3 Hz), 2.52 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-methoxybenzylamine Hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; ARANCIO, Ottavio; FIORITO, Joie; WASMUTH, Andrew; WO2013/109738; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics