4863-91-6, Name is 3-Chloro-5-fluoroaniline, 4863-91-6, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
To a cooled (0 C) solution of 3-chloro-5-fluoroaniline (5.0 g, 33 mmol) in MeCN (50 ml) was added a suspension of N-bromosuccinimide (5.9 g, 33 mmol) in MeCN (10 ml). After being stirred for 2 h at RT the reaction was quenched by adding 10 % NaHS03 (50 ml). The mixture was concentrated to about half of the volume, diluted with water (50 ml) and extracted with EtOAc (3×50 ml). Combined organic phases were dried over Na2S04 and evaporated to give crude product, which was purified by CombiFlash (column: silica, eluent: 0-100 % EtOAc in heptane) to yield 5.5 g (74 %) of the title compound. -NMR (400MHz; d6-DMSO): delta 5.88 (bs, 2H), 6.45 (dd, IH), 6.64 (m, IH).
Statistics shows that 3-Chloro-5-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 4863-91-6.
Reference:
Patent; ORION CORPORATION; WOHLFAHRT, Gerd; TOeRMAeKANGAS, Olli; SALO, Harri; HOeGLUNG, Lisa; KARJALAINEN, Arja; KNUUTTILA, Pia; HOLM, Patrick; RASKU, Sirpa; VESALAINEN, Anniina; WO2011/51540; (2011); A1;,
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