A common heterocyclic compound, 108-70-3, name is 1,3,5-Trichlorobenzene, molecular formula is C6H3Cl3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 108-70-3.
General procedure: Palladium(II) acetate (0.025 mmol, 5.6 mg), XPhos (0.0375 mmol, 17.9 mg), and phenylsilatrane (2a, 0.75 mmol, 188.5 mg) were added to a Schlenk flask. The flask was then purged with nitrogen. 4-Chloroanisole (1a) (0.50mmol, 71.3 mg), toluene (1.5 mL), and TBAF (0.75 mmol, 0.75 mL in ca. 1.0 M THF solution) were subsequently added. The mixture was stirred at 100 C for 3 h, then quenched by addition of water, and extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered,and concentrated in vacuo. The crude product was purified by flash column chromatography on silica gel (hexane) to provide 3a (75.2 mg, 0.408 mmol) in 82% yield.
The synthetic route of 1,3,5-Trichlorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yamamoto, Yutaro; Baralle, Alexandre; Godefroy, Anais; Murakami, Kei; Yorimitsu, Hideki; Osuka, Atsuhiro; Heterocycles; vol. 95; 1; (2017); p. 568 – 574;,
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