The chemical industry reduces the impact on the environment during synthesis 13526-66-4, name is 3-Bromo-6-chloroimidazo[1,2-b]pyridazine, I believe this compound will play a more active role in future production and life. 13526-66-4
75. 2-(trans-4-((3-(3-fluorophenyl)imidazof1,2-blpyridazin-6- yl)amino)cvclohexyl)propan-2-ol (EX. 8-75) [00463] To a solution of 3-bromo-6-chloroinnidazo[1 ,2-b]pyridazine (500 mg, 2.15 mmol) in a mixed solvent of dioxane (5 ml_) and water (0.5 ml_) was added (3-fluorophenyl)boronic acid (273 mg, 1 .96 mmol), K2CO3 (81 1 mg, 5.88 mmol) and Pd(dppf)2Cl2 (79 mg, 0.098 mmol). The reaction mixture was stirred at 80C overnight under N2. TLC (PE: EA = 5:1 ) showed the starting material was consumed. The mixture was cooled and concentrated. The residue was purified by column chromatography on silica gel (petroleum ether/EtOAc = 20:1 to 1 :1 ) to give 6-chloro-3-(3-fluorophenyl)imidazo[1 ,2-b]pyridazine (300 mg, 56%) as a yellow solid.
The chemical industry reduces the impact on the environment during synthesis 13526-66-4. I believe this compound will play a more active role in future production and life.
Reference:
Patent; TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan; WO2013/13188; (2013); A1;,
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