A common heterocyclic compound, 98577-44-7, name is 1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane, molecular formula is C5H6Br2Cl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 98577-44-7.
Tricyclo [1.1.1.01’3] pentane Methyllithium (46.3 mL, 74.1 mmol, 1.6M in diethyl ether) was added to a solution of l,l-dibromo-2,2-bis(chloromethyl)cyclopropane (10 g, 33.7 mmol) in pentane (10 mL) stirred at -78C for 15 min. After the reaction mixture was maintained at -78C for 15 min, the reaction flask was removed from the dry ice/acetone bath and placed in an ice-water bath. The reaction mixture was stirred at that temperature for 2 hrs. The volatiles, which was warmed at 40C by using an oil bath, were collected via a shortpath distillation condenser under a dry-ice-acetone environment. The condensed material was used in next reaction without further purification.
The synthetic route of 1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YEUNG, Kap-Sun; EASTMAN, Kyle J.; PARCELLA, Kyle E.; WO2014/159559; (2014); A1;,
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