The chemical industry reduces the impact on the environment during synthesis 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, I believe this compound will play a more active role in future production and life. 1871-57-4
Part 2; A mixture of (2S)-benzylamino-succinic acid 1-benzyl ester 4-tert-butyl ester (12.1 g, 32.6 mmol), K2CO3 (14 g, 3 equiv.), NaI (3.0 g, 20 mmol) and 1-chloro-2-chloromethyl-1- propene (5.1 g, 40.8 mmol) in MeCN (150 mL) was stirred at 81C for 16 h. After cooling, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. Purification by Combiflash (hexane and ethyl acetate: gradient 0 to 8% during 12 min) afforded (2S)- [benzyl- (2-chloromethyl-allyl)-amino]-succinic acid 1-benzyl ester 4-tert-butyl ester (8.7 g, 58%). MS (ESI): 458 (M + H+).
The chemical industry reduces the impact on the environment during synthesis 1871-57-4. I believe this compound will play a more active role in future production and life.
Reference:
Patent; INCYTE CORPORATION; WO2005/37826; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics