The chemical industry reduces the impact on the environment during synthesis 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride, I believe this compound will play a more active role in future production and life. 13918-92-8
To 5-bromo-2-methoxy pyridine-3-amine (6.3g, 31mmol) pyridine (25 ml) is added to solution of 2,4-difluoro-1-sulfonyl chloride (16.47g, 77 . 5mmol). Reaction liquid in 23 C stirring 24 hours, concentrated under reduced pressure, the volume of the solution to the original 1/2. Filtering, collecting solid, solid with i-PrOH (5mLx2) and Et 2 O (5 ml) washing. The resulting solid and NaOH (2.48g, 62mmol) suspended in MeOH (25 ml) in, the reaction solution 23 C stirring 1 hour, concentrated under reduced pressure. For residual DCM (20 ml) and 2M hydrochloric acid (20 ml) is diluted, by 5% NaHCO 3 pH7 aqueous solution is adjusted to the rear, with DCM (20mLx3) extraction. Merger of the first organic phase and the salt water (20 ml) washing, anhydrous Na 2 SO 4 drying, and concentrating under reduced pressure, to obtain the title compound as a buff solid (8.2g, 69.9%).
The chemical industry reduces the impact on the environment during synthesis 13918-92-8. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd. / Sunshine Lake Pharma Co., Ltd; Jiata Science company; Xi, Ning; Li, Zhuo; Wang, Tingjin; Wu, Zuping; Wen, Qiuling; (65 pag.)CN103539777; (2016); B;,
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