6940-78-9, Name is 1-Bromo-4-chlorobutane, 6940-78-9, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
50 g of 7-hydroxy-1H-quinolin-2-one and 400 mL of ethanol and 62.7 g of triethylamine were charged into a 1 L three-necked reaction flask and heated to 60 C,Then 159.5 g of 1-bromo-4-chlorobutane was added dropwise,The temperature was raised to 80 C and the reaction was kept at reflux for 2 hours.The reaction was stopped,Cooled to 10 C,Stirred for 1 hour,The crude product was collected by filtration and then recrystallized from 500 ml of methanol. After heating to reflux, the mixture was cooled to room temperature, stirred for 1 hour, filtered, rinsed with cold methanol 50 mL and dried at 60 C under normal pressure to give 72.0 g. G, yield: 92.2%, HPLC purity 99.5% (1: 2.0)
Statistics shows that 1-Bromo-4-chlorobutane is playing an increasingly important role. we look forward to future research findings about 6940-78-9.
Reference:
Patent; SHANDONG CHUANGCHENG PHARMACEUTICAL CO., LTD; Guo, Ming; Ma, Juliang; Liu, Huaizhen; (6 pag.)CN106008337; (2016); A;,
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