The chemical industry reduces the impact on the environment during synthesis 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, I believe this compound will play a more active role in future production and life. 1996-29-8
In a sealed tube, to a stirred solution of ferf-butyl (3-(2-oxoimidazolidin-1 – yl)bicyclo[1 .1 .1 ]pentan-1 -yl)carbamate (0.25 g, 0.935 mmol, 1 .0 equiv.) in 1 , 4-dioxane (5 mL) was added 1 -bromo-4-chloro-2-fluorobenzene (0.19 g, 0.935 mmol, 1 .0 equiv). The mixture was degassed by purging with argon for 5 minutes. Then Pd2(dba)3 (0.085 g, 0.093 mmol, 0.1 equiv), xanthphos (0.1 g, 0.187 mmol, 0.2 equiv) and Cs2C03 (1 .21 g, 3.74 mmol, 4.0 equiv) were added to the reaction mixture under argon atmosphere, and the sealed tube was capped and the mixture was stirred at 80 C for 16 h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (20 mL), filtered through a Celite bed, and the Celite bed washed with excess ethyl acetate. The filtrate was concentrated under reduced pressure to afford the crude product, which was purified by silica gel column chromatography (Combiflash) using 50 % Ethyl acetate in hexane as eluent to obtain ferf-butyl 3-(3-(4-chloro-2-fluorophenyl)-2-oxoimidazolidin-1 – yl)bicyclo[1 .1 .1 ]pentan-1 -yl)carbamate (0.17 g, 65% yield) as an off-white solid. LCMS (ES) m/z = 396.1 [M+H] +.
The chemical industry reduces the impact on the environment during synthesis 1996-29-8. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey Michael; DEMARTINO, Michael P.; EVANS, Karen Anderson; RALPH, Jeffrey M; KALITA, Biswajit; (278 pag.)WO2018/225093; (2018); A1;,
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