112-26-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-26-5 name is 1,2-Bis(2-chloroethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A 50 mL round-bottomed flask was sequentially charged with 8 mmol of N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-yl). Base) benzamide compound 1, 30 mmol 1,2-bis(2-chloroethoxy)ethane, 10 mmol anhydrous potassium carbonate, and 20 mL N,N-dimethylformamide (DMF). The reaction was stirred overnight at 60 degrees Celsius, extracted with ethyl acetate and dried over anhydrous sodium sulfate.The solvent was removed on a rotary evaporator and the residue was chromatographed on a silica gel column to give the product 4-((4-(2-(2-(2-chloroethoxy)ethoxy)ethyl)piperazin-1-yl)methyl. (amino)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide compound m (yield: 72%)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Bis(2-chloroethoxy)ethane, and friends who are interested can also refer to it.
Reference:
Patent; Hefei Zhong Popular Science Ruisheng Bio-pharmaceutical Technology Co., Ltd.; Liu Qingsong; Liu Jing; Wang Qiang; Liu Feiyang; Wang Beilei; Wang Aoli; Wang Wenchao; Hu Chen; Chen Cheng; Zhao Zheng; Wu Hong; Wang Li; (52 pag.)CN104844566; (2018); B;,
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