60811-21-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60811-21-4 name is 4-Bromo-2-chloro-1-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Grignard solution: To a solution of 2-propylmagnesium chloride (2M in THF, 263 ml, 525 mmol) under an Argon atmosphere was added a solution of 1,3-dibromo-5-fluorobenzene (100 g, 477 mmol) in THF (250 ml) dropwise and then stirred for 60 mins at rt. A solution of ethyl 3,3,3-trifluoro-2-oxopropanoate (60 ml, 450 mmol) in anhydrous THF (1 L) was cooled to -700 under an argon atmosphere. To t his solution was added the grignard solution slowly ensuring the reaction temperature did not exceed -65. Ton complete addition the reaction was stirred at -70 for 3h. The react ion was quenched by the addition of aqueous hydrochloric acid (1 M, 500 ml). The organic layers were extracted with DCM, dried over sodium sulfate, filtered and concentrated under reduced pressure to give the title compound (133.36g) which was used directly in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-chloro-1-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; GRAHAM, Keith; BUCHGRABER, Philipp; AIGUABELLA FONT, Nuria; HEINRICH, Tobias; BRAeUER, Nico; KUHNKE, Lara, Patricia; WITTROCK, Sven; LANGE, Martin; BADER, Benjamin; PRECHTL, Stefan; LIENAU, Philip; KOPITZ, Charlotte, Christine; NOWAK-REPPEL, Katrin; POTZE, Lisette; STEUBER, Holger; HARVEY, Rebecca, Ann; KIRK, Ralph, Steven; (699 pag.)WO2020/48829; (2020); A1;,
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