1435-48-9, A common heterocyclic compound, 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, molecular formula is C6H3Cl2F, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2,4-Dichloro-1-fluorobenzene (165.0 g, 1.0 mol) in THF (500 mL) n-BuLi (420 mL, 2.5 M, 1.05 mol) was added at -78 C. After stirring at -78 C for 1 h, Oxirane (44.0 g, 1.0 mmol) was added and stirred at -78 C for 2 h. The mixture was quenched with sat. NH4Cl solution, extracted with EtOAc (200 mL * 3). The organic phase was washed with water (100 mL * 2), brine (100 mL * 2), dried over Na2SO4. After filtering, the organic phase was concentrated to give compound 44 as a colorless liquid (156.7 g, 75.0% yield). 1H NMR (400 MHz, CDCl3) delta 7.29-7.25 (m, 1H, Ar-H), 7.02-6.97 (m, 1H, Ar-H), 3.89-3.84 (m, 2H, CH2), 3.29-3.24 (m, 2H, CH2).
The synthetic route of 2,4-Dichloro-1-fluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Na; Wang, Yanfen; Huang, Gongchao; Ji, Conghui; Fan, Wei; Li, Haitao; Cheng, Ying; Tian, Hongqi; Bioorganic Chemistry; vol. 65; (2016); p. 146 – 158;,
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