Related Products of 33863-76-2,Some common heterocyclic compound, 33863-76-2, name is 1-Bromo-3-chloro-5-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : 1-Bromo-3-chloro-5-methoxybenzene. 1 -Bromo-3-chloro-5-fluorobenzene (1 g, 4.77 mmol, 1 equiv.) was treated at 0 C with sodium methoxide (25 % in MeOH, 1.2 ml_, 5.71 mmol, 1.2 equiv.). The reaction mixture was stirred at 100 C for 3 h. The solution was concentrated under reduced pressure, the crude product was extracted with DCM, washed with H20, brine, dried over MgS04 and concentrated. The product was obtained as a white solid (747 mg, 71 %). LCMS [M+H]+ 220; 1 H NMR (400 MHz, CD3CI) 5 7.09 (1 H, t, J = 1 .7 Hz), 6.94 – 6.92 (1 H, m), 6.83 – 6.80 (1 H, m), 3.77 (3H, s).
The synthetic route of 33863-76-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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