These common heterocyclic compound, 89794-02-5, name is 4-Bromo-2-chlorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Bromo-2-chlorotoluene
(i) Alkoxycarbonylation reactions of different aryl bromides using different phosphonium salts 0.0025 mmol Pd(OAc)2, 0.0075 mmol ligand (phosphonium salt) and 0.385 mmol TMEDA were diluted with n-butanol to a total volume of 10 ml. 0.5 mmol of each substrate was introduced directly in the autoclaves, and then 1 ml of the catalyst solution was added to the autoclave. After purging with carbon monoxide the pressure was set to 25 bar CO and the autoclave was stirred while warming up to 115C. The reactions were hold at 115C for 20h. After cooling down and releasing the pressure the raw mixtures were filtered through a short path of Al2O3 and the conversion was determined via GC.
The synthetic route of 4-Bromo-2-chlorotoluene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Evonik Degussa GmbH; EP1894938; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics