Reference of 54932-72-8, The chemical industry reduces the impact on the environment during synthesis 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene, I believe this compound will play a more active role in future production and life.
A mixture of 7-amino-2,2-dimethyl-2H-l,4-benzoxazin-3(4H)-one (compound obtained in Reference Example 3(1); 150 mg), 5-bromo-2-chlorotoluene (321 mg), copper(I) iodide (37 mg), potassium carbonate (216 mg), N,N’-dimethylethylenediamine (40 muL) and toluene (8 mL) was heated at 110 C overnight under argon atmosphere. After cooling, to the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel (solvent; n-hexane/ethyl acetate = 4/1 -? 1/1) to give 7-amino-4-(4-chloro- 3-methylphenyl)-2,2-dimethyl-2H-l,4-benzoxazin-3(4H)-one (98 mg) as a pale orange powder.MS(APCI) m/z: 317/319 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-chloro-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2007/89034; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics