Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1124-05-6, name is 2,5-Dichloro-p-xylene, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8Cl2
A mixture of l,4-dichloro-2,5-dimethylbenzene (5 g, 0.03 mol, 1.0 eq), NBS (10.5 g, 0.06 mol) and AIBN (50 mg, 0.3 mmol) in CCL (200 mL) was heated at 85 C under N2 for 2 h. The solvents were evaporated, diluted with water (200 mL) and extracted with DCM (100 mL X 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated. The residue was purified via flash chromatography (PE) to afford l,4-bis(bromomethyl)-2,5-dichlorobenzene as a white solid (850 mg, 10%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
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