In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 39226-96-5
Example 8 /V-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-4- imidazolidinecarboxamide (E8) (e.g. in a form obtainable or prepared from (4S)-2- oxo-S-^phenylmethy^oxyJcarbonylJ^-imidazolidinecarboxylic acid); Crude 3-methyl-2-oxo-4-imidazolidinecarboxylic acid (-0.63 mmol, prepared as described below) was dissolved in dimethylformamide (3 ml) and treated with 1- hydroxybenzotriazole (0.094 g, 0.69 mmol), N-(3-dimethylaminopropyl)-N’- ethylcarbodiimide hydrochloride (0.132 g, 0.69 mmol), [(2-chloro-3- trifluoromethylphenyl)methyl]amine (0.145 g, 0.69 mmol) and N-ethylmorpholine (0.169 ml, 1.32 mmol). The mixture was stirred at 22C for 20 hours then reduced in vacuo to give a residue which was purified by mass-directed automated HPLC to give lambda/-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-4- imidazolidinecarboxamide as a white solid (0.105 g). LC/MS [M+H]+ = 336, retention time = 2.18 minutes.
The synthetic route of 39226-96-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/119825; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics