Related Products of 2106-04-9, These common heterocyclic compound, 2106-04-9, name is 3-Chloro-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A suspension of compound 5 (1.70 g, 6.75 mmol) and 3-chloro-2-fluoroaniline (982 mg, 6.75 mmol) in i-PrOH (50 mL) was heated to reflux for 3 h. The solvent was removed under vacuum, and the residual was recrystallized in CH3CN to afford 6 (2.51 g, 93%) as a pale brown solid, mp 209-210 C. 1H NMR (DMSO-d6): d 9.82 (br s, 1H), 8.48 (s, 1H), 8.23 (s, 1H), 7.53-7.47 (m, 2H), 7.37 (s, 1H), 7.28 (t, J = 8.0 Hz, 1H), 3.96 (s, 3H), 2.37 (s, 3H). LC-MS (ESI, m/z): calcd for C17H14ClFN3O3 ([M+H]+) 362.0, found 362.0.
The synthetic route of 2106-04-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 24; 18; (2014); p. 4455 – 4459;,
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