Related Products of 61881-19-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows.
Cs2C03 (3.0 equiv.), CF3C(NPh)CI (3.0 equiv.) were added to a stirred solution of 22 in DCM (10 mL/1 g) at 0C. After 10 min., the mixture was brought to rt and stirred for 1 h. After complete consumption of 22, reaction mixture was filtered, and the filtrate was concentrated. The obtained crude residue was purified by automated flash column chromatography on silica gel (0-60% EtOAc in cyclohexane) to afford the desired imidate donor 23 (87%) as foam.
The chemical industry reduces the impact on the environment during synthesis 2,2,2-Trifluoro-N-phenylacetimidoyl chloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; VAXXILON AG; EMMADI, Madhu; LISBOA, Marilda P; KNOPP, Daniel; MONNANDA, Bopanna; VON BONIN, Arne; PEREIRA, Claney Lebev; (309 pag.)WO2020/104697; (2020); A1;,
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