Related Products of 367-21-5,Some common heterocyclic compound, 367-21-5, name is 3-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-chloro-4-fluoroaniline (5.82 g, 0.04 mol) in CH2Cl2(150 mL), N-bromosuccinimide (7.12 g, 0.04 mol) was added in portions at 0C under stirring. Upon completion of the addition, the resultant was stirred for 30 minutes and filtered. The filtrate was concentrated and purified by silica gel column chromatography to give 2-bromo-5-chloro-4-fluoroaniline (6.16 g, 69% yield). 1H-NMR (400 MHz, CDCl3):delta = 7.234 (d, J = 8.4 Hz, 1H), 6.788 (d, J = 6.4 Hz, 1H), 3.982 (br, 2H). MS m/z [ESI]: 225.9 [M+1].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-4-fluoroaniline, its application will become more common.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Centaurus BioPharma Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XIAO, Dengming; XU, Xinhe; LIU, Xijie; HU, Yuandong; YU, Honghao; LIU, Zhihua; PENG, Yong; SUN, Yinghui; LUO, Hong; KONG, Fansheng; HAN, Yongxin; SUN, Jian; EP2952510; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics