Reference of 14495-51-3, The chemical industry reduces the impact on the environment during synthesis 14495-51-3, name is 2-Bromo-5-chlorotoluene, I believe this compound will play a more active role in future production and life.
Compound 3 (20.7 mmol) was dissolved in CH2Cl2 (150 mL) and cooled to 0 C. with ice bath. To this solution under nitrogen were added in sequence N,N-di-isopropyl ethyl amine (5.4 mL, 31.02 mmol, 1.5 eq) and chloromethyl methyl ether (2 mL, 25.85 mmol, 1.25 eq). The reaction mixture was stirred overnight at room temperature and washed with NaHCO3-saturated water and then NaCl-saturated water. The residue after rotary evaporation was purified by flash column chromatography over silica gel to give 17.6 mmol of 4.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-chlorotoluene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Baker, Stephen J.; Sanders, Virginia; Akama, Tsutomu; Bellinger-Kawahara, Carolyn; Freund, Yvonne; Maples, Kirk R.; Plattner, Jacob J.; Zhang, Yong-Kang; Zhou, Huchen; Hernandez, Vincent S.; US2007/293457; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics